Personnel capture of CDC leadership with anti-vaccine ideology represents significant institutional damage. Capture driver scores maximum (5) as this is textbook regulatory capture - placing ideologically opposed figure in control of public health agency. Civil_rights (3) reflects direct threat to public health infrastructure and vaccine policy affecting population health. Rule_of_law (2) and corruption (2) reflect circumvention of normal scientific/merit-based appointment processes. Mechanism modifier 1.4 applies for personnel_capture with clear ideological opposition to agency mission. Scope modifier 1.3 for federal agency with broad population impact. Severity: durability 1.2 (appointee can reshape agency culture/policy), reversibility 0.9 (can be removed but damage to institutional credibility persists), precedent 1.1 (normalizes ideological capture of scientific agencies). B-score elevated by outrage (anti-vax controversy), media friendliness (clear narrative), and strategic timing within broader RFK Jr. HHS context. However, constitutional damage substantially exceeds hype with D=+15.25, clearly qualifying for List A.